The origins of Xochimilco date back to the Mesoamerican Preclassic Period when its shores and islands were home to various peoples. At the beginning of the Postclassic, Xochimilco was an important altépetl that was subdued by the Mexica in the 15th century. From then until the 60s of the 20th century, the territory of Xochimilco became one of the suppliers of food for the Mexican capital.

In the territory of Xochimilco there are 14 native peoples that preserve many features of their traditional culture and indigenous heritage, despite the advance of urbanization. In addition, the southern mountains and the central lake area are part of the largest natural reserve In contrast, the northern area of Xochimilco is fully integrated into the urban area of Mexico City, and in it are located some industrial and service areas that constitute an important part of the economic life of the delegation.

Coyoacán is a place name of Nahuatl origin. In this way, it can be translated as Place of the owners of coyotes.

Before the conquest, Coyoacán was a Tepaneca tlahtocáyotl whose limits extended far beyond those of the current mayor's office: the towns of San Ángel, Mixcoac, Tacubaya, Tlalpan, Contreras, Cuajimalpa, among the main ones, and even the towns of Ajusco and the forests where today the Desierto de los Leones is located were part of the pre-Columbian manor of Coyoacán. This tlahtocáyotl was assigned to the great altépetl of Azcapotzalco

Around the arrival of the Spanish in Mexico, Coyoacán was one of the altépetl subject to Mexico-Tenochtitlan. At that time it was governed by Cuauhpopoca, related by marriage alliances with the Mexican tlatoanis and administrator of the Totonacapan lands. Cuauhpopoca shared —with other members of the Tenochca realm such as Cacama— the opinion that it was necessary to fight the Spaniards, who had entered the Mexican dominions through the north of the current state of Veracruz. In April 1519 the Totonacs, supported by the Spanish, tried to resist paying the tribute to Mexico-Tenochtitlan.

The Diego Rivera Anahuacalli Museum (Casa del Anahuac) is a museum in Mexico City, it is located to the south in the Coyoacán mayor's office.

It was designed by the exponent of Mexican muralism Diego Rivera to house his vast collection of pre-Columbian pieces, one of the largest in the country, which he collected since his return from Europe in 1920. Returning to characteristics of Teotihuacan and Mexican architecture, Diego Rivera He planned this space as a place where various expressions of art such as theater, dance, painting and music would take place, immersed in an atmosphere whose architecture is a search for the essence of the Mexican through its rich pre-Columbian past.

The Blue House is the Intimate Universe of Frida Kahlo. In this beautiful residence, the artist lived most of her life; initially with her family and years later, with Diego Rivera. Likewise, interesting Mexican and foreign visitors stayed in this place, attracted by the captivating couple of artists.

Frida wanted to leave her house as a museum, to learn and enjoy her beloved Mexico. For this reason, after his death, Diego organizes the Frida Kahlo Museum here.